Pseudorabies Virus Fast Axonal Transport Occurs by a pUS9-Independent Mechanism.
نویسندگان
چکیده
Reactivation from latency results in transmission of neurotropic herpesviruses from the nervous system to body surfaces, referred to as anterograde axonal trafficking. The virus-encoded protein pUS9 promotes axonal dissemination by sorting virus particles into axons, but whether it is also an effector of fast axonal transport within axons is unknown. To determine the role of pUS9 in anterograde trafficking, we analyzed the axonal transport of pseudorabies virus in the presence and absence of pUS9.
منابع مشابه
The pseudorabies virus protein, pUL56, enhances virus dissemination and virulence but is dispensable for axonal transport.
Neurotropic herpesviruses exit the peripheral nervous system and return to exposed body surfaces following reactivation from latency. The pUS9 protein is a critical viral effector of the anterograde axonal transport that underlies this process. We recently reported that while pUS9 increases the frequency of sorting of newly assembled pseudorabies virus particles to axons from the neural soma du...
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عنوان ژورنال:
- Journal of virology
دوره 89 15 شماره
صفحات -
تاریخ انتشار 2015